Clinical applications of three-dimensional time-resolved (4D) flow MRI are still hindered by long acquisition times. Using compressed sensing image reconstruction, undersampled 4D flow data may be recovered without a notable loss of image quality. In this study pseudo-spiral sampling on a Cartesian grid was implemented on a Philips 3T Ingenia system to facilitate random undersampling in time. The technique was tested under controlled conditions in a pulsatile phantom for different acceleration factors. An additional in vivo volunteer data set confirmed the stability of this technique.