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Abstract #1267

Differentiated maturation of white matter tracts in early developing brain aged 0-3 years

Qinlin Yu1,2,3,4, Huiying Kang1,5, Qinmu Peng1,2, Minhui Ouyang1,2, Michelle Slinger1,2, Yun Peng5, Fang Fang3,4, and Hao Huang1,2

1Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States, 2Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 3School of Psychological and Cognitive Sciences, Peking University, Beijing, People's Republic of China, 4Peking-Tsinghua Center for Life Science, Peking University, Beijing, People's Republic of China, 5Department of Radiology, Beijing Children’s Hospital, Capital Medical University, Beijing, People's Republic of China

The brain development in the first several years after birth is perhaps most dynamic. However, the studies on white matter maturation of infants and toddlers with relatively evenly distributed ages in 0-3 years are rare. Here, we charted white matter development in subjects 0-3 years-of-age through measurements of DTI-derived metrics at the tract level and tract-group level. A 3-stage maturational pattern was revealed for all white matter tracts. The differentiated maturation among the white matter tracts and tract groups was found using DTI measurements.

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