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Abstract #1306

Impact of image registration on renal T1 mapping in children with chronic kidney disease

Fabio Nery1, Enrico De Vita2,3, Chris A. Clark1, Isky Gordon1, and David L. Thomas3

1UCL Great Ormond Street Institute of Child Health, Developmental Imaging and Biophysics Section, London, United Kingdom, 2National Hospital for Neurology and Neurosurgery, Lysholm Department of Neuroradiology;, 3UCL Institute of Neurology, Department of Brain Repair and Rehabilitation

Renal longitudinal relaxation time (T1) is an established indicator of pathophysiological tissue status. We have applied image registration techniques to correct for motion during saturation recovery (SR) acquisitions with multiple recovery times used for T1 mapping in kidneys of paediatric patients. All registration techniques were successful in improving the intra and inter-session repeatability of the T1 estimates, as well as the quality of the underlying saturation recovery fits on a challenging patient population, as assessed by intra- and inter-scan repeatability and analysis of the root mean squared error of the SR fits.

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