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Abstract #1334

Zero-echo-time PET/MRI attenuation correction shows good correlation between 15O-water PET and simultaneously acquired ASL in standard regional flow territories

Markus Fahlström1, Karolina Lindskog2, Lieuwe Appel1, Mathias Engström3, Johan Wikström1, Gunnar Antoni4, Eva Kumlien5, Elna-Marie Larsson1, and Mark Lubberink1

1Surgical Sciences, Uppsala University, Uppsala, Sweden, 2Biomedical Technology, Medical Physics and IT, Uppsala University Hospital, Uppsala University Hospital, Uppsala, Sweden, 3Applied Science Laboratory, GE Healthcare, Uppsala, Sweden, 4Medicinal Chemistry, Uppsala University, Uppsala, Sweden, 5Neuroscience, Uppsala University, Uppsala, Sweden

Zero-Echo-Time (ZTE) MRI for attenuation correction (AC) in hybrid PET/MRI-systems is a promising method. This study aims to examine reproducibility between 15O-water PET and simultaneously acquired Arterial Spin Labelling (ASL) using ZTE-MRI AC and the reproducibility between to subsequent ASL measurements. Measurements were performed on six subjects on an integrated 3.0 T PET/MRI-system. Regional cerebral blood flow (CBF) values from standard flow territories were compared. ASL showed good correlation with 15O-water PET, presenting another advantage of ZTE-MRI AC. A significant decrease between ASL measurements was detected, which may be important to consider when designing PET/MRI-studies.

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