The parameter mapping accuracy of MR Fingerprinting (MRF) relies on specific signal patterns for each set of parameters. Choice of sequence design and acquisition parameters are two aspects that affect this. We optimised the TR and Flip Angle (FA) of a selection of simulated single-shot MRF designs, based on Inversion-Recovery Gradient Echo (IR-GRE), GRE, Spin Echo (SE) and IR-SE sequences. We compared the parameter assignment accuracy of each optimised design. Our results suggest that GRE-based sequences should be used for single-shot MRF.