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Abstract #1350

Quality Factors for Efficient and Precise MRF Imaging

Danielle Kara1, Mingdong Fan1, Jesse I. Hamilton2, Nicole Seiberlich2,3, Mark Griswold2,3, and Robert Brown1

1Physics, Case Western Reserve University, Cleveland, OH, United States, 2Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 3Radiology, University Hospitals Case Medical Center, Cleveland, OH, United States

With the invention of MRF imaging, there is considerable freedom in input parameter selection, but it is difficult to determine how each choice affects the resulting parameter maps. Quality factors are introduced as a means of comparing MRF sequences with various input parameters (FA, TR, TE, N) on their abilities to precisely quantify T1 and T2. Simulations, fully sampled, and undersampled experiments verified that sequences with higher quality factors result in lower standard deviations in R1 and R2. With quality factor analysis, researchers and clinicians can readily determine the appropriate MRF input parameters to image more efficiently and precisely.

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