In vivo magnetic resonance elastography (MRE) experiments on Alzheimer’s disease (AD) mouse model were conducted. The AD and Control mice were in the age group of 3-4 months (n = 4 for both). Median stiffness values for the overall mouse brain (central axial slices) and for the hippocampus region were calculated. No differences were observed between the two groups for the overall brain. For the hippocampus region, a trend of cerebral stiffness decrease in AD was measured. The small sample size did not allow for statistically significant conclusions. Further experiments are underway.