Quantitative Susceptibility Mapping (QSM) offers unique, quantitative information about tissue magnetic susceptibility. A multi-orientation method, calculation of susceptibility through multi-orientation sampling (COSMOS), enables the dipole inversion by acquiring data at multiple orientations. In practical imaging settings, however, it is a challenge to image the subject multiple orientations. Although small angle COSMOS has been shown to generate reasonable QSM images, the selection of orientations within a practical acquisition protocol remains an open question. In this work, we investigated the influence of the number and direction of orientations on the outcome of small angle COSMOS for in vivo imaging.