Transverse relaxation time (T2) maps were assessed as a potential marker for the long-term follow-up of the patients with cartilage lesions ICRS Grade I-II in four time points (baseline, 8 days, 3 and 6 months). T2 mapping was based on a 3D triple echo steady state imaging sequence delivering high quality high-resolved T2 maps at ultra-high field MRI. The results showed opposite trends of T2 values at 3T (a decrease) and 7T (an increase) over time. The statistically significant difference was found in case of deep zone of the cartilage lesion at 3T. T2 mapping could be used in the future as a good alternative to cartilage biopsies in clinical trials on new therapies aimed at cartilage regeneration.