MusculoSkeletal (MSK) MRI is used for analyzing injuries, and the knee injury is one of the common injuries reported in sports. Current work uses Compressed Sensing (CS) based reconstruction technique called Region Of Interest Compressed Sensing (ROICS). The proposed method has been demonstrated on five datasets at chosen acceleration factors. The reconstructed images are compared with the reference images using line intensity profile and NRMSE graph to demonstrate the utility of the proposed ROICS method on MSK MRI. The qualitative and quantitative result shows that ROICS performs better than CS. Current and future work involves the prospective implementation of ROICS on MSK MRI.