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Abstract #1544

T1ρ acquired at higher Spin Lock Frequency and Composite R2 - R1ρ are better predictors of Patient-Reported Outcome in Osteoarthritis

Taylor Jan Leong1, Valentina Pedoia1, Colin Russell1, and Sharmila Majumdar1

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States

Synopsis: The agreement and associations of T1p values with different spin lock frequencies were evaluated for the detection of radiographic knee OA and association with patient-reported outcomes. Analyses were performed in vivo at 3T MRI. Significant differences were identified between FSL 500 Hz, 3 TSL and T2 in all knee compartments and between FSL 700 Hz, 3 TSL and FSL 500 Hz, 3 TSL. While similar behavior was observed in distinguishing radiographic OA, T1ρ computed at higher FLS (700 Hz) and R2-R1ρ 700Hz demonstrated a better association with patient-reported outcomes.

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