Muscular dystrophy is a family of inherited diseases characterized by progressive muscle weakness that leads to muscle damage and wasting, and in the case of Duchenne muscular dystrophy (DMD), is fatal. Clinical measures of muscular dystrophy rely on surgical biopsy, which is invasive and provides a limited overview of the disease’s progression. Magnetic resonance imaging (MRI) may provide valuable information pertaining to tissue characteristics of this disease. We performed multi-parametric MRI to assess the changes in young dystrophic mice. The changes observed in skeletal muscles demonstrate MRI parameters may be used to track disease progression and future treatment options.