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Abstract #1565

Semi-automated analysis of diaphragmatic motion with cine MRI in controls and non-ambulant Duchenne Muscular Dystrophy (DMD) patients

Courtney Bishop1, Rexford Newbould1, Valeria Ricotti2, Christopher Sinclair3, Jordan Butler3, RB Matt Evans3, Jasper Morrow3, Mike Hanna3, Paul M Matthews4, Tarek Yousry3, John Thornton3, Francesco Muntoni3, and Robert Janiczek5

1Imanova, London, United Kingdom, 2UCL, Institute of Child Health, London, United Kingdom, 3University College London, 4Imperial College London, United Kingdom, 5GlaxoSmithKline, Brentford, United Kingdom

This study presents both an analysis pipeline for measuring diaphragmatic motion from cine MRI data, and the application of this image processing technique to investigate exploratory MRI endpoints of respiratory function in both healthy controls and non-ambulant DMD boys. Cine-derived metrics of diaphragm motility and contractility correlated with sitting spirometry-derived forced vital capacity, and showed relationships with disease progression surrogates of age and months non-ambulatory, as well as a longitudinal change over 12 months. Longitudinal changes were not seen in spirometry measures.

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