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Abstract #1566

Potential of Stimulated Echo Diffusion-weighted Imaging as Disease Marker in Duchenne Muscular Dystrophy

Bauke Kogelman1, Maaike van Putten2, Matt Hall3, Chris Clark3, Andrew Blamire4, Paola Porcari4, and Louise van der Weerd1,2

1Radiology, LUMC, Leiden, Netherlands, 2Human Genetics, LUMC, Leiden, Netherlands, 3Institute of Child Health, University College London, London, United Kingdom, 4Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle, United Kingdom

We used stimulated echo diffusion weighted imaging (STE-DWI) in a mouse model of Duchenne muscular dystrophy (mdx). From the data in mdx or wild type animals we observe that although muscle fibre size is smaller in the mdx mouse, the diffusion data show increased diffusibility – opposite to the hypothesised effect if fibre size is the main determinant of restricted water diffusion. Muscle fibre permeability is significantly greater in the mdx mouse, suggesting that the overall system permeability has a countering effect on diffusion restriction. Additional modelling is required to capture these two opposing effects.

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