The relationship between localized histological truth and various MRI quantitative measures were investigated using canine models. In this study, GRMD pectineus muscle samples were imaged on a 3T clinical scanner and a 4.7T small-bore scanner. Trichrome stained histology slice was registered to the 3D MRI volume. Localized quantitative MRI parameters are correlated with histology analysis (muscle, fibrosis and interstitial tissue percentage). Parameters derived from the 4.7T MRI data show consistent correlations, while those from 3T MRI data do not show consistent correlation.