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Abstract #1576

Perturbed muscle mitochondrial function in Sarcopenia

Jamie XM Ho1, Stacey KH Tay2, Subhasis Banerji 3, and Mary C Stephenson4

1A*STAR-NUS Clinical Imaging Research Centre, Singapore, Singapore, 2Division of Paediatric Genetics and Metabolism, National University Hospital, 3National University of Singapore, 4A*STAR-NUS Clinical Imaging Research Centre

In this study we use 31P MRS in combination with Near Infra-red Spectroscopy to assess muscle mitochondrial function and changes in oxygenation in patients with Sarcopenia as to date, the etiology and molecular mechanisms of sarcopenia remain poorly understood. 10 males diagnosed with sarcopenia and 10 healthy controls were scanned where 31P MRS: A fully relaxed 31P MR spectrum data and exercise paradigm were acquired. MVC were significantly different between the sarcopenic and healthy groups (p=0.0044). Despite this, there was a tendency for increased ATP turnover in patients compared with healthy controls (44% and 66% MVC (ATP turnover p= 0.5642 44%MVC, p= 0.6128 66%MVC). Patients with sarcopenia showed significantly higher oxidative ATP synthesis ATP at 66%MVC where p= 0.0477. These results indicate that at least some of this increased requirement can be met oxidatively, with no contribution from breakdown of PCr at the end of exercise.

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