Less may be better: comparison of Multi-Echo-ICA de-noising for three and four echo EPI acquisitions in studies of seed-based functional connectivity

This work is a formal comparison between different echo acquisitions (3 and 4 echo) for the use with multi-echo independent component analysis de-noising of resting-state functional MRI data. We look to evaluate and determine the optimal acquisition required for de-noising of resting state data which is often plagued with artifacts and noise.