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Abstract #1657

Quantifying the dynamics of cerebral blood flow, oxygen metabolism, and deoxygenated blood volume with a combined normoxia/hyperoxia method

Eulanca Y. Liu1,2,3, Frank Haist4,5, David J. Dubowitz3,6, and Richard B. Buxton3,6

1Neurosciences Graduate Program, University of California, San Diego, La Jolla, CA, United States, 2Medical Scientist Training Program, University of California, San Diego, La Jolla, CA, United States, 3Center for Functional MRI, University of California, San Diego, La Jolla, CA, United States, 4Psychiatry, University of California, San Diego, 5Center for Human Development, University of California, San Diego, 6Radiology, University of California, San Diego

To better understand the dynamics of the BOLD response in terms of CBF, CMRO2, and deoxygenated blood volume, we used a combined normoxia/hyperoxia approach to untangle their relative contributions. This method was applied to both the positive activation response and the post-stimulus undershoot, the origins of which are still debated. A simple model of the BOLD response based on flow, metabolism, and volume, modified to include the effects of hyperoxia, was applied. For the origin of the undershoot, these data provide strong evidence for a CBF undershoot, moderate evidence for elevated CMRO2, and no evidence for elevated CBV (Balloon Model).

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