Abstract #1670

Neural and Physiological Responses to Vagus Nerve Stimulation in rats

Jiayue Cao¹, Kun-Han Lu², Matthew Ward¹, Terry Powley^1,3, and Zhongming Liu^1,2

¹Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ²Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States, ³Psychological Sciences, Purdue University, West Lafayette, IN, United States

Vagus nerve stimulation (VNS) is an electroceutical treatment for both brain and visceral organs disorders. To better understand its function in autonomic brain-body interaction, we applied electrical stimulation to the vagus nerve to perturb brain activity and visceral organ physiology. By simultaneously measuring the VNS-induced brain and physiological responses, we separated the afferent neuronal and efferent physiological effects of VNS on the blood oxygen level dependent functional magnetic resonance imaging responses and mapped part of the brain’s autonomic control networks modulated by VNS. This work offers a unique way to characterize the brain-activation profile of VNS with variable parameters.

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