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Abstract #1684

The impact of geometric distortion correction on multisite rs-fMRI data

Nicolas Hehn1,2, Ana Beatriz Solana Sánchez1, Dirk Bequé1, Nikolaos Koutsouleris3, Axel Haase2, Bjoern Menze4, and Carlos Cabral3

1GE Global Research, Munich, Germany, 2Department of Medical Engineering, Technische Universität München, Munich, Germany, 3Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany, 4Department of Informatics, Technische Universität München, Munich, Germany

This study addresses the goal of reducing site-variance in the correlation values of multisite rs-fMRI data by correcting for site-specific EPI-related geometric distortions. Three geometric distortion correction methods (B0 fieldmap and image-based unwarping) were applied separately to a calibration dataset consisting of six subjects traveling to three sites. The change of the correlation values and their site-homogeneity was evaluated in dependency of the quantified geometric distortion correction values for six networks and all subjects. It could be shown that the distortion correction had no significant impact on the correlation values and no correlation between the two parameters was found.

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