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Abstract #1697

Greater Connectivity Between Cerebellar Vermis and Insular Attention Resting Network in HIV Patients

Steffan Soosman1, Thomas Ernst1, and Linda Chang1

1John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, United States

Individuals infected with HIV frequently have HIV-associated neurocognitive disorders (HAND), despite effective plasma viral suppression. Various resting state networks studied with fMRI have been shown to be attenuated in HIV compared to seronegative controls. This study shows an increased connectivity in HIV subjects between the cerebellar vermis and bilateral insulae. Using clinical correlates, we conclude that this increased connectivity may be due to decreased efficiency in functional connectivity in the HIV-infected brain.

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