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Abstract #1721

Modulation of Saslience Network Activation after 4 Weeks Verbal Training in Older Adults

Toshiharu Nakai1,2, Ayuko Tanaka3,4, Mika Ueno1, Atsunobu Suzuki5, and Sachiko Kiyama4,6

1NeuroImaging & Informatics, NCGG, Ohbu, Japan, 2Department of Radiological Science, Nagoya University Graduate School of Medicine, Nagoya, Japan, 3Faculty of Human Sciences, Kobe Shoin Women's University, Kobe, Japan, 4NeuroImaging & Informatics, National Center for Geriatrics & Gerontology, Ohbu, Japan, 5Department of Social and Human Environment, Graduate School of Environmental Studies, Nagoya, Japan, 6College of Liberal Arts and Sciences, Mie University, Tsu, Japan

The potential of RSN to detect the early change of neuronal networks induced by short-term cognitive intervention was investigated by using a verbal training task to read short sentences aloud everyday for 4 weeks. Twenty community dwelling older adults participated in this study. Activation in the anterior SN was decreased after the training, suggesting optimization of salience processing to integrate visual information and language production. The SN may be potentially a biomarker to firstly reflect the change in response to cognitive interventions in older adults and this finding may be applied to optimize training protocols for each individual.

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