In this study, we replicated previous findings about spatially distinct thalamic correlations with cortical regions of interest. Using bi-directional functional analysis, we firstly clarified cortical-subcortical activity during hyperthermic condition by thalamocortical functional connectivity. Specifically, we found weakening connectivity of cortical fronto-polar/anterior cingulate cortex and prefrontal areas with the corresponding thalamic nuclei. On the contrary, the motor/premotor and somatosensory cortical subdivisions showed increased connectivity with thalamic nuclei. The thalamic pulvinar showed reduced connectivity with bilateral superior and middle temporal pole, but increased connectivity with bilateral middle and inferior temporal gyrus.