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Abstract #1744

A novel diffusion compartment imaging (DCI) model that captures the asymmetry of WM microstructure heterogeneity

Benoit Scherrer1, Maxime Taquet1,2, Etienne Saint-Onge1, Gaetan Rensonnet2, and Simon K Warfield3

1Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, 2ICTEAM, Universite catholique de Louvain, Louvain-La-Neuve, Belgium, 3Boston Children's Hospital, Harvard Medical School, Boston, MA, United States

The DIAMOND diffusion compartment imaging (DCI) model has been recently proposed to model the 3-D diffusivity of each compartment with a statistical distribution of diffusion tensors. This enabled the assessment of compartment-specific diffusion characteristics while also capturing the intra-compartment heterogeneity. The approach, however, could only describe symmetric heterogeneity, while tissue heterogeneity likely differs along and perpendicular to the fascicles' orientation. In this work we propose a new statistical distribution model able to capture the asymmetric nature of tissue heterogeneity. We demonstrate that it captures different axial and radial heterogeneities in presence of dispersion and investigate results with in vivo data.

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