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Abstract #1753

In-vivo whole-brain Neurite Orientation Dispersion and Density Imaging at sub-millimeter scale using gSlider-SMS

Elda Fischi-Gomez1,2, Susie Y. Huang1,2, Hui Zhang3, and Kawin Setsompop1,2

1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital. Department of Radiology, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Department of Computer Science & Centre for Medical Image Computing, University College London, United Kingdom

We demonstrate the feasibility of applying microstructural models of diffusion to sub-millimeter isotropic resolution whole brain images in-vivo. The NODDI model was successfully fitted to a 700┬Ám DWI dataset acquired using the generalized SLIce Dithered Enhanced Resolution Simultaneous MultiSlice (gSlider-SMS) acquisition1. We demonstrate the ability to map finer-scale structures using this high-resolution data when compared to traditional multi-shell 2 mm isotropic acquisition.

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