Effective representation of the diffusion signal's dependence on diffusion time is a sought-after challenge in diffusion MRI (dMRI). As a solution, we recently proposed Multi-Spherical Diffusion MRI (MS-dMRI) to represent the dMRI signal in this four-dimensional space - varying over gradient strength, direction and diffusion time. Our representation allows for the estimation of time-dependent q-space features, providing unique insights on the tissue microstructure. In the study, we assess test-retest reproducibility of these indices in three C57Bl6 wild-type mice. We find that due to our effective regularization methodology during signal fitting, these time-dependent features can be estimated reliably without overfitting the data.