This study investigated the reliability of using a rapid three b-value diffusion-weighted imaging to determine intravoxel incoherent motion (IVIM) parameters. Grey matter simulations were conducted to assess the bias and reproducibility of the parameters with b-value distributions: b0,300,500,1000, b0,500,1000 and b0,300,1000. The same b-value distributions were assessed with a volunteer cohort. The results showed that the use of two high b-values provided a good estimate of the perfusion fraction, which was further improved by an increase in the SNR level. In conclusion, the measurement of IVIM-f was achievable using a three b-value protocol.