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Abstract #1835

Fiber connection density differences detected in patients with sickle cell disease

Julie Coloigner1, Jacob Antony1, Roza Vlosova2, Adam Bush3, Soyoung Choi4, Maxime Descoteaux5, Jean-Christophe Houde5, Thomas Coates6, Natasha Lepore2, and John Wood7

1Radiology, Children's hospital Los Angeles, Los Angeles, CA, United States, 2Radiology, Children's hospital, Los Angeles, CA, United States, 3Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, 4Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, United States, 5Sherbrooke Connectivity Imaging Lab (SCIL), Computer Science Department, University of Sherbrooke, Sherbrooke, QC J1K 0A5, Canada, 6Hematology, Children's hospital, Los Angeles, CA, United States, 7Cardiology, Children's hospital, Los Angeles, CA, United States

Sickle cell disease (SCD) is a chronic disorder characterize by progressive cerebrovascular damage. We hypothesized that subtle cerebral injury might be visible with diffusion imaging data in these patients. Tractography based on the fiber orientation distribution function (ODF) was applied in order to investigate the character and severity of white matter injury in patients with SCD. We found both decreased and increased fiber density in patients, compared to control subjects that co-localized with silent cerebral infarctions. These data suggest progressive white matter injury and compensatory mechanisms in SCD patients.

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