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Abstract #1844

Harmonization for DTI measurements mapping across sites in multi-center MRI study

Chuanzhu Sun1, Lijun Bai1, Hao Yan2,3, Shan Wang1, Xiaocui Wang1, Xianjun Li1,4, Chao Jin5, Xiaocheng Wei6, Hong Yin7,8, Zengjun Zhang9, Xiaoqun Yao10, Xiaoling Zhang11, Jian Yang5, Jian Yang5, and Jian Yang5

1Department of Biomedical Engineering, the Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Xi'an Jiaotong University, Xi'an, People's Republic of China, 2Xidian University, Xidian University, People's Republic of China, 3Center for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen University, shenzhen, People's Republic of China, 4Department of Radiology, the First Affiliated Hospital, Xi’an Jiaotong University, xi'an, People's Republic of China, 5Department of Radiology, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, People's Republic of China, 6MR Research China, GE Healthcare, Beijing, People's Republic of China, 7Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China, 8Department of Radiology, Xijing Hospital, Fourth Military Medical University, xi'an, People's Republic of China, 9Department of Diagnostic Radiology, Xi’an Children Hospital, Xi'an, People's Republic of China, 10Department of Radiology, Xi’an Gao Xin Hospital, Xi'an, People's Republic of China, 11Department of MRI Diagnosis, Shannxi Provincial People’s Hospital, Xi'an, People's Republic of China

Despite the fact that multi-site diffusion imaging studies are increasingly used to study brain disorders, but it is noteworthy that there are large differences among diffusion measurements from different sites. The current study aimed to confirm the variability and to harmonize data across sites. Our results indicated that not only DTI metrics in human brain within inter-site but also within inter-site changed obviously. Furthermore, a brain voxel-based model was developed to harmonize the DTI metrics and to reduce the deviation compared with reference site data and thus improve the reliability of group analysis in multi-center study.

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