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Abstract #1876

Signal behavior of Ultra-High-b radial DWI (UHb-rDWI) signal in different tract of the cervical spinal cord

Bijaya Thapa1,2, Nabraj Sapkota1,2, YouJung Lee1, EunJu Kim1, John Rose3, Lubdha M. Shah4, and Eun-Kee Jeong1,4

1Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States, 2Department of Physics and Astronomy, University of Utah, Salt Lake City, UT, United States, 3Department of Neurology, University of Utah, Salt Lake City, UT, United States, 4Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States

The ultrahigh-b radial DWI (UHb-rDWI) technique is used to study the white matter disease in the spinal cord. The diffusion signal from the extra axonal (EA) space drops to noise level while that from the intra axonal (IA) space is almost constant at UHb region for the myelinated axons where the myelin layers prohibit the exchange of water molecules between IA and EA spaces. However for partially or unmyelinated axons, the diffusion signal from IA space is no longer constant. The signal behavior at UHb region could be used as a biomarker for the demyelination and axonal loss.

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