Abstract #1880

Cerebral Blood Flow and Bolus Arriving Time Changes in Patients with Diabetes Detected by Multi-TI ASL

Yelong Shen¹, Bin Zhao¹, Lirong Yan², Kay Jann², Guangbin Wang¹, Junli Wang¹, Bao Wang¹, Josef Pfeuffer³, Tianyi Qian⁴, and Danny JJ Wang²

¹Shandong Medical Imaging Research Institute, School of Medicine, Shandong University, Jinan, People's Republic of China, ²Laboratory of FMRI Technology (LOFT)，Mark & Mary Stevens Neuroimaging and Informatics Institute，Keck School of Medicine，University of Southern California (USC), LA, CA, United States, ³Siemens Healthcare, Erlangen, Germany, ⁴Siemens Healthcare, MR Collaborations NE Asia, Beijing, People's Republic of China

This study aimed to simultaneously measure cerebral blood flow (CBF) and bolus arriving time (BAT) in a cohort of subjects with type II diabetes, and compared the results with those of matched control subjects using a multi-TI 3D GRASE pulsed-ASL (PASL) sequence. The voxel-based analysis showed that the CBF and BAT values in patients with diabetes presented significant differences compared to healthy subjects, especially in some particular areas of the brain. These differences may be related to functional changes in patients with diabetes, which may have occurred before the onset of the symptoms.

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