Perfusion and diffusion imaging both represent powerful tools in order to phenotype mouse models of brain diseases. Indeed, imaging cerebral blood flow (CBF) may be seen as a surrogate marker of brain metabolism while diffusion imaging provides the structural aspects of brain wiring. To evaluate the potential of combined CBF/Diffusion phenotyping, we evaluated the effect of knocking-out (KO) the microtubule-associated protein 6 (MAP6), which plays a critical role during the development of cerebral axonal tracts. Experiments were performed on homogeneous C57Bl6/129Sv mice using 3D pseudo-continuous Arterial Spin Labeling (pCASL) and 3D diffusion tensor imaging (DTI) at 9.4T.
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