Abstract #1895

Perfusion decrease during radiochemotherapy is not fully explained by volumetric gray matter changes

Jan Petr¹, Henri JMM Mutsaerts^2,3, Frank Hofheinz¹, Iris Asllani⁴, Matthias JP van Osch⁵, Ivan Platzek⁶, Annekatrin Seidlitz^7,8,9,10, Mechthild Krause^7,8,9,10,11, and Jörg van den Hoff^1,12

¹PET center, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, ²Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Canada, ³Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, ⁴Rochester Institute of Technology, Rochester, NY, United States, ⁵Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁶Department of Radiology, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany, ⁷Department of Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany, ⁸OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden, Germany, ⁹German Cancer Consortium (DKTK), Dresden, Germany, ¹⁰German Cancer Research Center (DKFZ), Heidelberg, Germany, ¹¹Institute of Radiooncology, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, ¹²Department of Nuclear Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany

Radiochemotherapy in brain-tumor patients was shown to cause gray matter (GM) volume and cerebral blood flow (CBF) changes. The interaction of these two effects, however, remains unclear. Here, we investigated GM volume and ASL CBF changes and their interaction in the healthy hemisphere of 38 glioblastoma patients undergoing radiochemotherapy with Temozolomide. We found a statistically significant CBF decrease with dependence on the RT-dose. PV-corrected results indicated that, while to a certain extent the apparent CBF decrease measured by ASL is caused by GM atrophy, there still remain significant CBF changes that cannot be explained by structural changes alone.

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