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Abstract #1934

Making Myelin Water Imaging Mainstream: Multi-site and Multi-vendor Reproducibility

Emil Ljungberg1, Julien Cohen-Adad2, Lisa Eunyoung Lee1, Alexander Rauscher3, David Li1,4, Anthony Traboulsee1, Alex MacKay4,5, Chase Figley6, Jongho Lee7, and Shannon Kolind1,4

1Medicine, Neurology, University of British Columbia, Vancouver, BC, Canada, 2Electrical Engineering, Polytechnique Montréal, Montreal, QC, Canada, 3Pediatrics, University of British Columbia, Vancouver, BC, Canada, 4Radiology, University of British Columbia, Vancouver, BC, Canada, 5Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 6Radiology, University of Manitoba, Winnipeg, MB, Canada, 7Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of

Myelin water imaging (MWI) is a quantitative T2 relaxation-based MRI technique, measuring the amount of myelin in the central nervous system. We investigated the reproducibility of MWI using GRASE with 3T MR scanners from two different vendors at two sites. Using stimulated echo correction, differences in the refocusing flip angle profile between the two sites were effectively corrected for and myelin estimates between the two sites were found to be highly correlated (slope=1.12, R2=0.96). This is the first multi-vendor and multi-site reproducibility study of MWI using GRASE, encouraging future multicenter MWI studies.

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