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Abstract #1940

Determination of Oxygenation Extraction Fraction for People with Sickle Cell Anemia using Calibration Model Specific to SCA Blood

Wenbo Li1,2, Xiang Xu1,2, Peiying Liu1, John Strouse3,4, Hanzhang Lu1, Peter van Zijl1,2, and Qin Qin1,2

1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Division of Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Division of Hematology, Duke University, Durham, NC, United States

For the blood T2-based MRI oximetry methods, the calibration model to convert blood T2 to blood oxygenation (Y) is critical to calculate the brain oxygen extraction fraction (OEF). Here, we established a calibration model specific to people with sickle cell anemia (SCA) using in vitro blood T2 measurements on SCA blood samples under various conditions. The results show that the use of calibration models based on normal blood underestimate Y, and thus overestimate OEF, for individuals with SCA. Using a fast T2 protocol to measure oxygenation in the internal jugular vein (IJV), the whole-brain OEF values of individuals with SCA were determined and compared with healthy volunteers.

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