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Abstract #1954

Susceptibility Mapping Reveals Inter-Hemispheric Differences in Venous Density in Patients with Brain Arteriovenous Malformations

Emma Biondetti1, Alvaro Rojas Villabona2, Anita Karsa1, Rolf J├Ąger2, David L Thomas3, and Karin Shmueli1

1Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom, 3Leonard Wolfson Experimental Neurology Centre, Institute of Neurology, University College London, London, United Kingdom

Brain arteriovenous malformations (AVMs) are vascular abnormalities characterised by arteriovenous shunting with the lack of a capillary bed. Recent studies have shown that it is possible to create diagrams of the cerebral vein network (venograms) from images of magnetic susceptibility ($$$\chi$$$). Here, we used $$$\chi$$$-based venograms to calculate the hemispheric percentage of venous voxels (venous density) in each hemisphere in AVM patients and healthy subjects. We found larger venous densities in the AVM-containing hemispheres than in the contralateral hemispheres, and more variable venous density in AVM patients than in healthy subjects.

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