Improved Measurement Precision for AACID CEST MRI of Brain pH using the 2 ppm Amine Resonance
Mohammed Albatany1,2 and Robert Bartha1,2
1Department of Medical Biophysics, University of Western Ontario, London, ON, Canada, 2The Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada
The chemical exchange saturation transfer (CEST) method called Amine and Amide Concentration Independent Detection (AACID) can produce image contrast that is dependent on tissue pH. The AACID value is calculated by taking the ratio of the 3.5 ppm amide CEST effect to the 2.75 ppm amine CEST effect and varies linearly with pH in the physiological range. In the current study, we compare the range of the AACID values obtained in 24 mice with brain tumors and normal tissue using the 2 ppm and 2.75 ppm amine resonances. Using the 2 ppm amine resonance increased the AACID range by 39% compared to the 2.75 ppm resonance and led to reduced measurement variability across the brain suggesting that using the 2 ppm amine resonance could improve AACID based pH measurement in-vivo.
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