Tumor metastasis accounts for the related mortality, and precise diagnostic imaging of distant metastasis plays a significant role in clinical administration and treatment plan. Enhanced MRI with small-molecule contrast agent (CA) is a favorite imaging modality. However, small-molecule CA has some unsatisfied flaws such as short blood circulation time, low relaxivity and non-specificity. In this study, we synthesized a macromolecular CA with high relaxivity and long blood circulation time, and assessed early liver metastasis with enhanced MRI using this macromolecular CA.
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