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Abstract #1996

MRI of Liver Cysts in Autosomal Dominant Polycystic Kidney Disease: Effect of Genotype

Zerwa Farooq1, Ashkan Heshmatzadeh Behzadi1, Jon Blumenfeld2, and Martin R Prince1,3

1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Nephrology, Weill Cornell Medicine, New York, NY, United States, 3Radiology, Columbia University, New York, NY, United States

ADPKD patients (n=25) undergoing abdominal MRI were analyzed 2 times each by 2 separate reviewers using a) thresholding; b) region growing c) cyst diameter d) semi-manual segmentation to determine liver cyst volume. Using the most reproducible technique, 75 additional ADPKD patients were studied correlating their liver parameters with genotype, gender and age. Semi-manual segmentation was the best technique for measuring cyst volume with intraclass correlation coefficient of 0.99. PKD1 mutation was found to be associated with higher total liver volume and liver cyst volume across different age groups and gender compared to PKD2 mutation, suggesting greater hepatic involvement with PKD1.

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