Radiation-induced liver injury (RILI) is one of the most dreaded complications of radiation therapy (RT)，which prevents radiation dose escalation and limits the effectiveness of the treatment . Therefore, it was important to predict and evaluate the RILI on hepatic malignancy using the RT in the early term. In this study, the ADCmid-RT value was significantly highest, and had negative correlation with the radiation dose. As the ADCmid-RT value was less than 1.29 x10-3mm2/s, the RILI could possibly occur. Therefore, the ADCmid-RT value may serve as a biomarker for predicting RILI in patients with hepatic malignancies treated with RT.