The range of R2* values estimated from MR sequences using low flip angles (FA) is limited by the background signal decay. The administration of contrast allows the use of higher FAs and increases the signal to noise ratio (SNR), allowing the estimation of a greater range of R2* values. We compared pre- and post-contrast R2* values in 158 patients and observed large discrepancies at R2* values greater than 300s-1. Our findings suggest that in patients with severe iron overload, post-contrast high-FA R2* mapping may be the preferred sequence for iron quantification.
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