Abstract #2081

Improved lymph node staging using MRI mDixon fat fraction measurements in patients with intermediate and high-risk prostate cancer

James O'Callaghan¹, Edward Johnston¹, Arash Latifoltojar¹, Harbir Sidhu¹, Magdalena Sokolska², Jamshed Bomanji³, Alan Bainbridge², and Shonit Punwani¹

¹UCL Centre for Medical Imaging, London, United Kingdom, ²Medical Physics, University College London Hospital, London, United Kingdom, ³Institute of Nuclear Medicine, University College London Hospital, London, United Kingdom

The staging of lymph nodes in prostate cancer is important for the planning and monitoring of treatments. However, there is currently a paucity of techniques that can accurately identify the presence of metastases in small nodes.

In this study, we investigate the usefulness of signal fat fraction from MRI mDixon acquisitions in discriminating between benign and metastatic nodes using ¹⁸F-Choline PET as a reference standard.

We present data suggesting that in comparison to commonly used diameter measurements, mDixon fat fraction may be better at discriminating benign from involved lymph nodes that are <10mm in short axis diameter.

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