The purpose of the study was to evaluate the clinical usefulness of IVIM technique for the PCa and furtherly investigate the diffusion and perfusion characteristics among PCa, normal peripheral zone (PZ) and central gland (CG) comparing to pharmacokinetic parameters based on quantitative DCE-MRI. The IVIM was performed at 11 b values of 0, 10, 20, 30, 50, 75, 100, 250, 500, 750 and 1000s/mm2. The
D value in prostate cancer were significantly lower than those
in the PZ and CG. The perfusion fractions in PCa were significantly higher than those in the PZ. There were no significant differences in the PCa, PZ and CG for the D*, which had large SDs. D showed significant negative correlations with Ktrans and Kep respectively, while f showed a significantly positive correlations with Ktrans and Kep. IVIM can provide more detailed information on perfusion and diffusion of prostate cancer noninvasively without intravenous contrast agent administration.