Ductal carcinoma in situ (DCIS) is a pre-invasive breast cancer that may be overtreated due to lack of reliable clinical and pathological prognostic features. Kinetics parameters on dynamic contrast-enhanced MRI have shown promise as breast cancer risk biomarkers. We compared imaging parameters of lesions and normal breast tissue between patients with DCIS recurrence and matched controls and found that patients with larger lesions with higher signal enhancement ratio (SER) and higher background parenchymal enhancement (BPE) on preoperative MRI were more likely to recur. These MRI biomarkers show promise for decreasing DCIS overtreatment and warrant further study in larger cohorts.
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