This work is to investigate the feasibility of compressed sensing (CS) on the morphologic measurement of lung microstructure using hyperpolarized 129Xe diffusion magnetic resonance imaging (MRI). The fully sampled (FS) and prospective CS multi-b diffusion MRI data were obtained from five healthy subjects and one COPD patient, respectively. The maps and global average values of mean linear intercept length (Lm) were calculated using cylinder model. The results were compared between FS and CS method for all subjects. The difference between FS and CS ranged from -2.3% to 7.2%. A highly Person’s correlation (R=0.988) between FS and CS was presented.