Abstract #2175

Behavioral and Image Evidence for Mild Traumatic Brain Injury in Rats with the Skull Helmet

Yu-Chieh Jill Kao^1,2, Chia-Feng Lu^1,2,3, Huai-Lu Chen^1,4, Ping-Huei Tsai^1,2,5, Fei-Ting Hsu^1,5, Hua-Shan Liu^1,6, Gilbert Aaron Lee^1,4, Paul Blakeley^1,4, Li-Chun Hsieh^1,5, Bao-Yu Hsieh⁷, and Cheng-Yu Chen^1,2,5

¹Translational Imaging Research Center, College of Medicine, Taipei Medical University, Taipei, Taiwan, ²Department of Radiology, School of Medicine, Taipei Medical University, Taipei, Taiwan, ³Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ⁴Department of Medical Research, Taipei Medical University Hospital, Taipei, Taiwan, ⁵Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan, ⁶School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ⁷Department of Biomedica, China Medical University, Taichung, Taiwan

An experimental model of mild traumatic brain injury (mTBI) mimicking the pathological outcomes in mTBI patients found in motorcycle accident was developed. The longitudinal behavioral and imaging assessment showed the functional deficit but intact brain structure in our model, which could be further used to explore early fluid and image biomarkers for mTBI

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