Mu opioid receptor (MOR) knock-out Oprm1-/- mice exhibit deficits in social behavior and repetitive behavior, which are phenotypes related with autism spectrum disorders (ASD). Thus, MOR deficient mice were recently proposed as monogenic models of ASD. Moreover, a decrease in metabotropic glutamate receptor 4 (mGluR4) levels was found in these mice. A treatment with VU0155041, an allosteric modulator of mGluR4, reversed behavioral deficits in Oprm1-/- mice. Here, we investigated the remodeling on brain connectivity level in Oprm1-/- mice under VU0155041-treatment and found enhancement of positive correlation towards frontal brain areas involved in reward-processing due to the compound.