Huntington’s Disease (HD) is a fatal neurodegenerative disorder, caused by a single genetic mutation, and characterized by deficits in motor coordination, behavior and cognition. A transgenic minipig model of HD has been established. Here, we employ single voxel MRS at 3 T to acquire metabolic profiles from the brain of this model over four years. We show that seven metabolite combinations can be quantified in adolescent and adult minipigs. Pathologic alterations in the phenotype were not observed at the age studied.