Abstract #2192

Developmental morphometry of the marmoset brain from infancy to adulthood

Stephen J Sawiak^1,2, Y Shiba³, L Oikonomidis³, C P Windle⁴, G Cockcroft⁴, E T Bullmore^1,5, and A C Roberts³

¹Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom, ²Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom, ³Dept of Physiology, Development and Neuroscience, University of Cambridge, ⁴Dept of Psychology, University of Cambridge, ⁵Dept of Psychiatry, University of Cambridge

Understanding the development of brain circuits through infancy to adulthood is crucial in determining the causes of mental health disorders, half of which are established before early adulthood. We use MRI to track the development of >200 discrete brain regions in a longitudinal primate brain study of 41 marmosets. Tensor-based morphometry indicated key regions of myelination from 3-6 months of age, and clustering of growth trajectories fitted with cubic splines allowed parcellation of regions based on growth patterns. We present maps of development showing differing patterns and rates of growth not only across lobes but between primary and associative areas.

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