In the treatment of gliomas, radiation therapy (RT) is associated with long-term effects including vascular injury in the form of cerebral microbleeds (CMBs), and changes in the white matter and thickness of cortex. Ultra high-field MRI techniques were used to characterize RT-induced changes across serial scans in support of ongoing investigations of the role of anti-angiogenic therapies in minimizing treatment effects. Steady increases in the number of CMBs was observed decades post-RT. CMB foci were characterized by increased isotropic diffusion when compared to surrounding white matter, which showed signs of degradation in as few as two months between serial scans.
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